Abstract: Objective The aim of this study was investigate the short-term efficacy of radiofrequency ablation (RFA) in patients with hepatic malignant tumors under ultrasound (US)- or US and CT combination-guidance. Methods A retrospective study was conducted on 96 patients with hepatic malignant tumors who underwent RFA under US and CT-guidance (group A) or US-guidance (group B) in our hospital from March 2017 through January 2019. All patients received RFA therapy, and were followed-up for three months. Results At the end of three months after RFA treatment, the total response rate in group A was significantly higher than that in group B (94.0% vs. 80.4%, P<0.05); after RFA treatment, there was no significant difference in incidence of complications between the two groups (4.0% vs. 13.0%, P>0.05); there were no significant differences as respect to serum creatinine and AFP levels between the two groups [(71.5±7.2) μmol/L vs. (70.6±7.3) μmol/L and (30.4±5.7) μg/L vs. (31.8±5.6) μg/L, respectively, P>0.05]. Conclusion The short-term efficacy of RFA guided by ultrasound and CT combination in the treatment of patients with hepatic malignant tumors is better as compared with routine ultrasound guidance, with low postoperative incidence of complications, which might be due to precise guidance and total ablation.

Key words: Liver malignant tumor, Ultrasound, Computed tomography, Radiofrequency ablation, Therapy