雷公藤多甙联合异甘草酸镁治疗儿童自身免疫性肝炎疗效及其对血清IL-17和CXCL10水平的影响

doi:10.3969/j.issn.1672-5069.2020.03.012

Abstract

Abstract: Objective The aim of this study was to explore the efficacy of combination of tripterygium wilfordii polyglycosides and magnesium isoglycyrrhizinate in the treatment of children with autoimmune hepatitis (AIH) and its effect on serum interleukin--17 (IL-17) and chemokin10 (CXCL10) levels.Methods 57 children with AIH were enrolled in the Department of Pediatric in our hospital between January 2018 and March 2019, and were randomly divided into observation (n=29) and control group (n=28). The children in the control group were treated with magnesium isoglycyrrhizinate injection intravenously, while those in the observation group were treated with tripterygium wilfordii polyglycosides orally at the basis of treatment mentioned above. Serum IL-17, CXCL8 and CXCL10 levels were detected by ELISA. Results At the end of the regimen, serum AST levels in the observation and control groups were (48.4±9.3) U/L and (61.2±12.50) U/L (P<0.05), serum levels of alkaline phosphatase were (60.2±5.1) U/L and (75.7±6.4) U/L (P<0.05), and serum levels of alanine aminotransferase were (59.3±7.6) U/L and (66.4±9.7) U/L (P<0.05); serum levels of immunoglobulin G were (13.8±2.9) mg/L and (16.3±3.4) mg/L (P<0.05), serum levels of immunoglobulin A were (2.4±0.3) mg/L and (2.9±0.5) mg/L (P<0.05), and serum level of immunoglobulin M were (2.6±0.3) mg/L and (3.1±0.4) mg/L (P<0.05); serum levels of IL-17 were (6.8±0.7) ng/ml and (7.3±0.9) ng/ml (P<0.05), serum level of CXCL8 were (10.4±1.2) pg/ml and (13.8±1.6) pg/ml (P<0.05), and serum levels of CXCL10 were (16.3±2.5) pg/ml and (22.6±3.7) pg/m (P<0.05) between the two groups; during the treatment, the incidence of adverse reactions was 12.5% in the observation group and 7.5% in the control group (P>0.05). Conclusion The combination of tripterygium wilfordii polyglycosides and magnesium isoglycyrrhizinate in the treatment of children with AIH is efficacious and safe, which might improve liver function and immune function tests and reduce inflammatory reaction.

Key words: Autoimmune hepatitis, Tripterygium wilfordii polyglycosides, Magnesium isoglycyrrhizinate, Interleukin-17, Chemokine 10, Therapy, Children

Du Ying, Jiang Zhihong, Wu Yaling. Efficacy of tripterygium wilfordii polyglycosides and magnesium isoglycyrrhizinate combination in the treatment of children with autoimmune hepatitis[J]. Journal of Practical Hepatology, 2020, 23(3): 348-351.

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Efficacy of tripterygium wilfordii polyglycosides and magnesium isoglycyrrhizinate combination in the treatment of children with autoimmune hepatitis

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