Abstract: Objective The aim of this study was to investigate the clinical efficacy of endoscopic tissue gel injection and sclerotherapy-ligation in the treatment of patients with esophageal and gastric varices (EGV). Methods 76 cirrhotic patients with EGV were recruited in our hospital from July 2017 through February 2019, and were randomly divided into control group (n=38) and combination group (n=38). The patients in the control group were treated with endoscopic ligation and those in the combination group were treated with endoscopic tissue glue injection and sclerotherapy-ligation combination. All patients were followed-up for 6 months. Results At the end of 6-month follow-up, 2 cases (5.3%) lost and 5 cases (13.2%) died in the control group, 3 cases (7.9%) lost and 2 cases (5.3%) died in the combination, and the total efficient rates were 71.0% in the control to 81.8% in the combination (P<0.05); the incidence of postoperative rebleeding, obstruction and esophageal stricture in the combination group was 24.2%, 18.2% and 15.2%, significantly lower than 41.9%, 35.5% and 25.8% (P<0.05) in the control. Conclusion Endoscopic tissue gel injection combined with sclerotherapy-ligation is efficacious in the treatment of cirrhotic patients with esophagogastric varices to prevent rebleeding with low incidence of adverse reactions, which worth further clinical investigation.

Key words: Liver cirrhosis, Esophageal and gastric varices, Endoscopic variceal ligation, Endoscopic sclerotherapy, Tissue gel injection, Therapy