索磷布韦/维帕他韦联合利巴韦林治疗慢性丙型肝炎患者疗效临床研究

doi:10.3969/j.issn.1672-5069.2021.01.009

Abstract

Abstract: Objective To investigate the clinical efficacy of sofosbuvir/vipatavir and ribavirin combination in the treatment of patients with chronic hepatitis C (CHC). Methods 105 patients with CHC were recruited in the Department of Hepatology in our hospital between May 2018 and May 2019, and were randomly divided into control (n=51) and observation group (n=5), receiving ribavirin and interferon-α-2b, or sofosbuvir/vipatavir and ribavirin combination treatment for three months. Serum cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), tumor necrosis factor alpha-induced protein 8-like molecule 2 (TIPE2), and interleukin-12 (IL-12) levels were detected by ELISA. Results The rapid virologic response (RVR) rate in the observation group was 88.9%, significantly higher than 43.1% (P<0.05) in the control, the early virologic response rate (EVR)was 90.7%, significantly higher than 52.9% (P<0.05) in the control, the end treatment virological response (ETVR) rate was 96.3%, significantly higher than 76.5% (P<0.05) and sustained virologic response (SVR) rate was 92.6%, much higher than 60.8% (P<0.05) in the control; the white blood cell count was (5.2±2.0)×10⁹/L, significantly higher than 【(3.4±1.8)×10⁹/L, P<0.05】, the red blood cell count was (4.9±0.5)×10⁹/L, significantly higher than 【(4.6±0.7)×10⁹/L, P<0.05】, and the platelet count was (113.2±38.6)×10⁹/L, significantly higher than 【(94.7±41.2)×10⁹/L, P<0.05】 in the control; serum CTLA-4 level was (1.1±0.4)ng/mL, much lower than 【(1.6±0.7)ng/mL, P<0.05】, serum IL-12 level was (29.6±7.3)pg/mL, much lower than 【(41.5±11.7)pg/mL, P<0.05】, while serum TIPE2 level was (0.8±0.1)μg/L, significantly higher than 【(0.6±0.3)μg/L, P<0.05】 in the control group; during the treatment period, the incidence of side effects was 25.9%, significantly lower than 94.1% (P<0.05) in the control.Conclusion The application of sofosbuvir/vipatavivir and ribavirin combination in treatment of patients with CHC is efficacious, which might be related to the strong direct anti-viral effect and the reduction of serum CTLA-4 and IL-12 levels, and increase of serum TIPE2 levels.

Key words: Hepatitis C, Sofosbuvir, Vepatavir, Ribavirin, Cytotoxic T lymphocyte associated antigen 4, Tumor necrosis factor alpha inducible protein 8-like molecule 2, Interleukin-12, Therapy

Fan Bingdong, Zhang Guohua, Wang Jun. An observation of clinical efficacy of sofosbuvir/vipatavir and ribavirin combination in the treatment of patients with chronic hepatitis C[J]. Journal of Practical Hepatology, 2021, 24(1): 31-34.

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An observation of clinical efficacy of sofosbuvir/vipatavir and ribavirin combination in the treatment of patients with chronic hepatitis C

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