慢性乙型肝炎和肝硬化患者血清HBV基因型分析

doi:10.3969/j.issn.1672-5069.2021.01.023

Abstract

Abstract: Objective To investigate the distribution of hepatitis B viral genotype in patients with chronic hepatistis B (CHB) and liver cirrhosis (LC). Methods 261 patients with CHB, 30 with LC and 4 with hepatocellular carcinoma (HCC) were recruited in this study, and HBV genotypes were determined by DNA sequencing. Results Among the 295 HBV infected patients, 132 (44.7%) were with genotype B infection, 161 (54.6%) were with genotype C infection, and 2 (0.7%) were with genotype D infection; 7 positive patterns of HBV serological markers were found in our series, and there were no significant differences with respect to serum bilirubin, ALT and AST between patients with CHB and patients with LC (P>0.05); the indexes of liver fibrosis(P<0.05), serum HBV DNA loads (P<0.05)and serum HBeAg positive rate(x²=5.798,P<0.05) in patients with cirrhosis were significantly higher than those with chronic hepatitis B; te proportions of genotype C in patients with LC and HCC were higher than that in patients with CHB(P<0.05).Conclusions The prevalence of HBV genotypes in patients with CHB and LC are predominantly genotype B and C, and the genotype C infections might lead to severe clinical outcomes.

Key words: Liver cirrhosis, Hepatistis B, Hepatistis B virus, Genotype

Song Jinyun, Wang Jianfang, Zhao Hongyu. Hepatitis B viralgenotypes in patients with chronic hepatitis B and cirrhosis[J]. Journal of Practical Hepatology, 2021, 24(1): 87-90.

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Hepatitis B viralgenotypes in patients with chronic hepatitis B and cirrhosis

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