Abstract: Objective The aim of this study was to investigate the modified sandwich endoscopic selective varices devascularization (ESVD) in the treatment of cirrhotics with esophagogastric varices (EGV). Methods A total of 106 patients with liver cirrhosis and EGV were encountered in our hospital between January 2018 and December 2022, and were randomly divided into observation and control group, with 53 cases in each group. All patients in the two groups were treated with anti-viral, non-selective β receptor blockers and supporting therapy, and those in the observation were given modified sandwich ESVD for sclerotherapy to remove EGV. The gastroscopy was conducted three months after for evaluation of the efficacy, and all patients were followed-up for one year. Results After endoscopic sclerotherapy, 5 patients (9.4%)in the observation group had non-disappearance of EGV, which disappeared after second operation; three months after sclerotherapy, the gastroscopy found the disappeared or decreased rate of EGV was 84.9%; serum albumin levels in the two groups increased greatly, and serum bilirubin, albumin and prothrombin time in the observation group were (16.2±1.4)μmol/L, (33.3±1.9)g/L and (11.3±0.4)s, not significantly different as compared to [(16.3±1.5)μmol/L, (33.4±1.8)g/L and (11.2±0.4)s, P>0.05] in the control; the post-operational complications included fever in 3 cases (5.7%), retrosternal pain in 3 cases (5.7%), abdominal pain in 1 case (1.9%), spontaneous bacterial peritonitis in 2 cases (3.8%) and esophageal ulcer in 5 cases (9.4%); at the end of one-year follow-up, the EGV bleeding (EGVB) occurred in 5 cases (9.4%) in the observation group, while it happened in 17 cases (32.1%) in the control, significantly different between the two groups (x²=5.079, P<0.05). Conclusion The modified sandwich ESVD could achieve a promising efficacy in dealing with patients with liver cirrhosis and EGV, which might eliminate the EGV and prevent EGVB.

Key words: Liver cirrhosis, Esophageal and gastric varices, Endoscopic selective varices devascularization, Endoscopic sclerotherapy, Therapy