JOURNAL OF PRACTICAL HEPATOLOGY ›› 2014, Vol. 17 ›› Issue (1): 5-8.doi: 10.3969/j.issn.1672-5069.2014.01.002
• Orignal Article • Previous Articles Next Articles
Wang Hongyan, Li Xin, Xu Youqing
Received:
2013-11-01
Online:
2014-02-28
Published:
2016-04-11
Wang Hongyan, Li Xin, Xu Youqing. Progress in the pathogenesis of alcoholic liver disease[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2014, 17(1): 5-8.
[1] Rehm JC,Mathers S,Popov A,et al. Global burden of disease and injury and economic cost attributable to alcohol use and alcohol-use disorders. Lancet, 2009, 373(9682):2223-2233. [2] 任燚,肖庆贵,邬吉伟,等. 酒精性肝病临床流调现状. 现代保健·医学创新研究,2008,5(35):55-56. [3] Gao B,Bataller R. Alcoholic liver disease:pathogenesis and new therapeutic targets. Gastroenterology,2011,141(5):1572-1585. [4] Ramstedt M. Alcohol and suicide in 14 European countries. Addiction,2001,96(Suppl 1):S59-S75. [5] Corrao GV,Bagnardi A,Zambon A,et al. A meta-analysis of alcohol consumption and the risk of 15 diseases. Prev Med,2004,38(5):613-619. [6] Kechagias S,Zanjani S,Gjellan S,et al. Effects of moderate red wine consumption on liver fat and blood lipids:a prospective randomized study. Ann Med,2011,43(7):545-554. [7] Zhou JY,Jiang ZA,Zhao CY,et al. Long-term binge and escalating ethanol exposure causes necroinflammation and fibrosis in rat liver. Alcohol Clin Exp Res,2013,37(2):213-222. [8] Shearn CT,Smathers RL,Jiang H,et al. Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis. J Nutr Biochem,2013,24(8):1436-1445. [9] Seth D,Haber PS,Syn WK,et al. Pathogenesis of alcohol-induced liver disease:classical concepts and recent advances. J Gastroenterol Hepatol,2011,26(7):1089-1105. [10] Stickel F,Hampe J. Genetic determinants of alcoholic liver disease. Gut,2012,61(1):150-159. [11] Xu JK,Lai K,Verlinsky A,et al. Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK. J Hepatol,2011,55(3):673-682. [12] Szabo G,Wands JR,Eken A,et al. Alcohol and hepatitis C virus—interactions in immune dysfunctions and liver damage. Alcohol Clin Exp Res,2010,34(10):1675-1686. [13] Mello T,Ceni E,Surrenti C,et al. Alcohol induced hepatic fibrosis:role of acetaldehyde. Mol Aspects Med,2008,29(1-2):17-21. [14] Kendrick SF,O'Boyle G,Mann J,et al. Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis. Hepatology,2010,51(6):1988-1997. [15] Cruz A,Muntane J. Alcoholic liver disease,oxidative stress, and antioxidants. Rev Esp Enferm Dig,2011,103(8):393-395. [16] Harrison-Findik DD,Schafer D,Klein E,et al. Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J Biol Chem,2006,281(32):22974-22982. [17] Albano E. Oxidative mechanisms in the pathogenesis of alcoholic liver disease. Mol Aspects Med,2008,29(1-2):9-16. [18] Sozio MD,Crabb W. Alcohol and lipid metabolism. Am J Physiol Endocrinol Metab,2008,295(1):E10-16. [19] Bardag-Gorce F,French BA,Nan L,et al. CYP2E1 induced by ethanol causes oxidative stress,proteasome inhibition and cytokeratin aggresome(Mallory body-like) formation. Exp Mol Pathol,2006,81(3):191-201. [20] Thakur V,Pritchard MT,McMullen MR,et al. Chronic ethanol feeding increases activation of NADPH oxidase by lipopolysaccharide in rat Kupffer cells:role of increased reactive oxygen in LPS-stimulated ERK1/2 activation and TNF-alpha production. J Leukoc Biol,2006,79(6):1348-1356. [21] Nieto N. Ethanol and fish oil induce NFkappaB transactivation of the collagen alpha2(I) promoter through lipid peroxidation-driven activation of the PKC-PI3K-Akt pathway. Hepatology,2007,45(6):1433-1445. [22] Rao R. Endotoxemia and gut barrier dysfunction in alcoholic liver disease. Hepatology,2009,50(2):638-644. [23] 李鑫,王晨,聂娇,等. 酒精性肝炎小鼠肝肠组织变化与内毒素血症的关系探讨. 实用肝脏病杂志,2013,16(3):254-256. [24] Rao RK,Seth KA,Sheth P. Recent advances in alcoholic liver disease I. Role of intestinal permeability and endotoxemia in alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol,2004,286(6):G881-G884. [25] Mutlu E,Keshavarzian A,Engen P,et al. Intestinal dysbiosis: a possible mechanism of alcohol-induced endotoxemia and alcoholic steatohepatitis in rats. Alcohol Clin Exp Res,2009,33(10):1836-1846. [26] Forsyth CB,Farhadi A,Jakate SM,et al. Lactobacillus GG treatment ameliorates alcohol-induced intestinal oxidative stress,gut leakiness,and liver injury in a rat model of alcoholic steatohepatitis. Alcohol,2009,43(2):163-172. [27] Kirpich IA,Solovieva NV,Leikhter SN,et al. Probiotics restore bowel flora and improve liver enzymes in human alcohol-induced liver injury:a pilot study. Alcohol,2008,42(8):675-682. [28] Elamin E,Jonkers D,Juuti-Uusitalo K,et al. Effects of ethanol and acetaldehyde on tight junction integrity:in vitro study in a three dimensional intestinal epithelial cell culture model. PLoS One,2012,7(4):e35008. [29] Li X,Wang C,Nie J,et al. Toll-like receptor 4 increases intestinal permeability through up-regulation of membrane PKC activity in alcoholic steatohepatitis. Alcohol,2013,47(6):459-465. [30] Tang Y,Forsyth CB,Farhadi A,et al. Nitric oxide-mediated intestinal injury is required for alcohol-induced gut leakiness and liver damage. Alcohol Clin Exp Res,2009,33(7):1220-1230. [31] Tang Y,Banan A,Forsyth CB,et al. Effect of alcohol on miR-212 expression in intestinal epithelial cells and its potential role in alcoholic liver disease. Alcohol Clin Exp Res,2008,32(2):355-364. [32] Szabo G,Bala S. Alcoholic liver disease and the gut-liver axis. World J Gastroenterol,2010,16(11):1321-1329. [33] Zhong W,McClain CJ,Cave M,et al. The role of zinc deficiency in alcohol-induced intestinal barrier dysfunction. Am J Physiol Gastrointest Liver Physiol,2010,298(5):G625-G633. [34] Voican CS,Perlemuter G,Naveau S. Mechanisms of the inflammatory reaction implicated in alcoholic hepatitis:2011 update. Clin Res Hepatol Gastroenterol,2011,35(6-7):465-474. [35] Ohtake T,Saito H,Hosoki Y,et al. Hepcidin is down-regulated in alcohol loading. Alcohol Clin Exp Res,2007,31(1 Suppl):S2-S8. [36] Endo M,Masaki T,Seike M,et al. TNF-alpha induces hepatic steatosis in mice by enhancing gene expression of sterol regulatory element binding protein-1c (SREBP-1c). Exp Biol Med (Maywood),2007,232(5):614-621. [37] Kang L,Sebastian BM,Pritchard MT,et al. Chronic ethanol-induced insulin resistance is associated with macrophage infiltration into adipose tissue and altered expression of adipocytokines. Alcohol Clin Exp Res,2007,31(9):1581-1588. [38] Jeong WI,Park O,Gao B. Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis. Gastroenterology,2008,134(1):248-258. [39] Roychowdhury S,McMullen MR,Pritchard MT,et al. An early complement-dependent and TLR-4-independent phase in the pathogenesis of ethanol-induced liver injury in mice. Hepatology,2009,49(4):1326-1334. [40] Cohen JI,Roychowdhury S,McMullen MR,et al. Complement and alcoholic liver disease:role of C1q in the pathogenesis of ethanol-induced liver injury in mice. Gastroenterology,2010,139(2):664-674. [41] Lemmers A,Moreno C,Gustot T,et al. The interleukin-17 pathway is involved in human alcoholic liver disease. Hepatology,2009,49(2):646-657. [42] Albano E,Vidali M. Immune mechanisms in alcoholic liver disease. Genes Nutr,2010,5(2):141-147. [43] Lian M,Hua J,Sheng L,et al. Prevalence and significance of autoantibodies in patients with alcoholic liver disease. J Dig Dis,2013,14(7):396-401. [44] Morales-Ibanez O,Dominguez M,Ki SH,et al. Human and experimental evidence supporting a role for osteopontin in alcoholic hepatitis. Hepatology,2013,58(5):1742-1756. [45] You M,Rogers CQ. Adiponectin:a key adipokine in alcoholic fatty liver. Exp Biol Med(Maywood),2009,234(8):850-859. |
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