Abstract: Objective To investigate the efficacy of Shengmai,a herbal medicine,alprostadil and reduced glutathione in treatment of patients with systemic inflammatory response syndrome（SIRS）. Methods Sixty-two patients with SIRS were randomly divided into two groups. Patients in control group（n=28） received basic treatment,and patients in treatment group（n=34） were given Shengmai,alprostadil and reduced glutathione injections intravenously for 7 days at the basic treatment. The serum levels of serum interleukin 6（IL-6）,IL-10,tumor necrosis factor alpha （TNF-α） and C reactive protein （CRP）,and incidences of multiple organ dysfunction syndrome（MODS） as well as mortality rates in the two groups were recorded and compared. Results After 7 day treatment,the levels of serum IL-6,TNF-α,IL-10 and CRP in patients in treatment group were（98.5±18.5） pg/ml,（31.8±9.5） ng/ml,（25.6±7.8） mg/ml and （92.5±24.5） μg/L,significantly lower than those in the controls [（180.6±34.5） pg/ml,（58.6±15.8） ng/ml,（40.5±10.2） mg/ml and 72.8±18.0） μg/L,respectively,P<0.01];The incidence of MODS in control patients was 35.6%,significantly higher than that in treatment group （11.8%,P<0.05）; The mortality rates of patients in treatment and in control group were 5.9% and 21.4%,respectively,which had no significant statistical difference（P>0.05）. Conclusions Shenmai,alprostadil and reduced glutathione injection were effective in blocking SIRS process,which might be related to the inhibition of inflammatory response.

Key words: Systemic inflammatory response syndrome, Shengmai injection, Alprostadil, Reduced glutathione, Therapy