Abstract: Objective The aim of this study was to analyze the clinicopathological features of patients with primary adenosquamous carcinoma(ASC)of liver. Methods The clinical and histopathological data of 6 patients with ASC were analyzed retrospectively, and all patients received hepatectomy and/or TACE. The hepatic tissue protein expression was detected by SP. Results In the six patients, two were women and four women, aged 54-75 yr with an average age of (63.0±8.3) yr; all patients presented with abdominal pain and intrahepatic foci were found by imaging examination; the gross foci mass was grayish white and solid with a relative clear border; the tumor cells were nested or glandular tubular microscopically; the SP detection showed the hepatic CK7, CK19, cam5.2 and Ki-67 positive in six, CEA positive in four, CK20 in three, CDX-2 in two and MUC-1 in one; the overall survival was 6 months. Conclusion The diagnosis of primary ASC of liver depends on the pathological examination, the tumor is malignant and the survival of patients is short.

Key words: Hepatoma, Primary adenosquamous carcinoma, Histopathology, Immunohistochemistry