Abstract: Objective The aim of this study was to explore the diagnostic accuracy of contrast enhanced ultrasound (CEUS) by liver imaging report and data system (LI-RADS) in patients with space-occupying liver lesions. Methods 60 patients were clinically confirmed with space-occupying liver lesions in our hospital between January 2018 and September 2019, and all underwent CEUS. The imaging was classified according to LI-RADS and the diagnostic accuracy was evaluated when LR-3 or LR-4a was assumed as cut-off value. Results Out of the 60 patients, the histopathological examination showed that there were 4 cases with hepatic cysts, 16 cases with hepatic hemangioma, 8 cases with liver abscess, 9 cases with focal hepatic steatosis, 9 cases with focal hepatic hyperplasia, 8 cases with hepatocellular carcinoma and 6 cases with liver metastases; when the pathological diagnosis was set as the gold standard, the LR-3 diagnosed malignant foci in 22, and benign lesions in 38 patients, and the LR-4a diagnosed malignant in 14 patients and benign foci in 46 patients; the sensitivity, specificity and accuracy by the the former were 85.7%, 78.2% and 80.0%, and by the latter were 78.6%, 93.5%(P<0.05)and 100.0%(P<0.05). Conclusion The LR-4a of LI-RADS from CEUS could be applied to differentiate liver lesions, which have a relatively good efficacy and warrants further investigation.

Key words: Space-occupying liver lesion, Contrast-enhanced ultrasound, Liver imaging reporting and data system, Diagnosis