Abstract: Objective The aim of this study was to investigate the risk factors of ischemia-type biliary lesions (ITBL) in recipients of liver transplantation (LT). Methods 312 patients with terminal benign and malignant liver diseases including 143 patients (45.8%) with primary liver cancer were recruited in our hospital between January 2015 and February 2019, and the ITBL was diagnosed according to the results of liver functions, cholangiography and imaging after LT. The clinical characteristics of ITBL in patients after LT were analyzed by donor and recipient-related clinical data, and univariate and multivariate Logistic regression analysis were performed. Results Postoperative ITBL occurred in 37 cases (11.9%), and 19 (51.4%) of them belonged to extrahepatic bile duct lesions; the Logistic regression analysis showed that the amount of infusion plasma (OR=1.175, P=0.006), the 1-week resistive index of hepatic artery (OR=8.891, P=0.030), acute rejection (OR=7.022, P=0.022), and cold ischemia time ≥11.5 h (OR=1.055, P=0.014) were the independent factors led to ITBL occurrence. Conclusion The recipients of LT are prone to developing ITBL, and the clinicians should take the common induced factors into consideration and deal with appropriately in time to achieve an optimal efficacy.

Key words: Liver transplantation, Ischemia-type biliary lesions, Hepatic artery resistance index, Acute rejection, Logistic regression analysis, Risk factors