Abstract: Objective The purpose of this study was to explore the clinical feature of and risk factors for nosocomial infections in patients with hospitalized decompensated hepatitis B liver cirrhosis. Methods 100 patients with decompensated hepatitis B liver cirrhosis were recruited in our hospital between February 2016 and December 2018. The clinical characteristics of patients with nosocomial infection were retrospectively analyzed, and the risk factors for infection were evaluated by Logistic regression analysis. Results Among the 100 patients with decompensated hepatitis B cirrhosis, 25 (25.0%) had nosocomial infection, and among them, 10 (40.0%) were respiratory tract infection, 7 (28.0%) were spontaneous bacteria peritonitis, 4(16.0%) were gut infection; the infected bacteria strains were Escherichia Coli in 5 (29.4%), Staphylococcus Aureus in 4(23.5%), Klebsiella Pneumonia in 2(11.8%), Pseudomonas Aeruginosa in 2(11.8%) and Streptococcus Pneumonia in 2(11.8%); univariate analysis showed that there were no significant differences between male and female patients, or patients with or without hepatic encephalopathy or prophylactic antibiotics(P>0.05), while there were significant differences between young and elderly patients, patients with short or long hospital stay, with different Child-Pugh scores, with or without invasive check-up, with lower serum albumin and bilirubin levels, with or without ascites and with or without anti-viral therapy and multivariate Logistic analysis showed that older than 60 years (OR=4.176, P=0.023), hospital stay longer than one month (OR=44.116,P=0.021), poor Child-Pugh score(OR=5.160,P=0.009), invasive check-up (OR=5.265, P=0.003) and ascites (OR=2.921, P=0.033) were the independent risk factors for nosocomial infections. Conclusion Patients with decompensated hepatitis B liver cirrhosis are prone to nosocomial infection, and clinicians should take risk factors into consideration in this settings to decrease the occurrence of nosocomial infection.

Key words: Liver cirrhosis, Nosocomial infection, Clinical features, Risk factors, Multivariate regression analysis