Abstract: Objective The aim of this study was to compare the clinical efficacy of fluorescent laparoscopic hepatectomy (FLH) and conventional laparoscopic hepatectomy (CLH) in the treatment of patients with hepatocellular carcinoma (HCC). Methods 148 patients with HCC were admitted to our hospital between August 2014 and August 2017, and were randomly divided into two groups,with 74 cases in each group. The patients in the control group underwent CLH, and those in the observation group underwent FLH. All patients were followed-up for 3 years. Results The tumor cell positive rate of surgical margins in the observation group was 2.7%, significantly lower than 13.5% in the control group(x²=5.804,P=0.016); there was no significant difference in perioperative period complications incidences such as pleural effusion, incision infection, bile leak and peritoneal bleeding in the two groups (P＞0.05); there were no significant differences as respect to six-month, 1-yearand 2-year survival rates (98.6%, 94.6% and 90.5% vs. 95.9%, 93.2% and 86.5%,P＞0.05) between the groups, but the 3-year survival rate in the observation group was85.1%, much higher than 70.3% in the control (P＜0.05); the 3-year tumor recurrence rate in the observation was 27.0%, significantly lower than 47.3% in the control group (P<0.05). Conclusion The fluorescent laparoscopic hepatectomy could visualize the incision margin of hepatic tumors which might improve the survival rate of patients with HCC.

Key words: Hepatocellular carcinoma, Fluorescent laparoscopic hepatectomy, Laparoscopic hepatectomy, Therapy