SMI、CDFI和增强CT检查TACE术治疗的原发性肝癌患者癌组织血供显像效果比较*

doi:10.3969/j.issn.1672-5069.2020.01.025

Abstract

Abstract: Objective The aim of this study was to investigate the efficacy ofultramicro-angiography (SMI), color Doppler flow imaging (CDFI) and enhanced computed tomography (CT) in detecting tumor blood supply in patients with primary liver cancer (PLC) after transcatheter arterial chemoembolization (TACE). Methods 135 patients with PLC were admitted to our hospital between April 2016 and April 2019, and all patients underwent TACE and received SMI,CDFI and enhanced CT scan 30 days after operation. Results The detection rates of tumor blood supply by SMI and CDFI were 54.2% and 25.0%, respectively, both significantly lower than 84.5% by enhanced CT (P < 0.05); for lesions with diameter < 2.0 cm, the tumor blood supply detection rate by SMI and CDFI were28.1% and 0.0%, respectively, both significantly lower than 73.7% by enhanced CT (P< 0.05), and for lesions with diameter ≥2.0 cm, the detection rate of tumor blood supply by SMI and CDFI were 67.6% and 37.8%, respectively, both significantly lower than 90.1% by enhanced CT(P＜0.05). Conclusion The application of enhanced CT scan in evaluating tumor blood supply after TACE in patients with PLC might be useful in clinical practice, and SMI and CDFI are simple, convenient and economical.

Key words: Hepatoma, Transcatheter arterial chemoembolization, Computed tomography, Color doppler flow imaging, Superb micro-vascular imaging, Blood supply

Chen Liang, Duan Haifeng, Yu Hongxing. Detection of tumor foci blood supply by SMI, CDFI and enhanced CT in patients with primary liver cancer after TACE[J]. Journal of Practical Hepatology, 2020, 23(1): 90-93.

References

[1] Zhang Y, Ren JS, Shi JF, et al. International trends in primary liver cancer incidence from 1973 to 2007. BMC Cancer, 2015, 15(1):94-104.
[2] 杨海青, 孙伟娜. TACE治疗PLC患者血清肿瘤标志物水平变化. 实用肝脏病杂志, 2018, 21(1):123-124.
[3] Zhang DW, Xu AX. Application of dual-source CT perfusion imaging and MRI for the diagnosis of primary liver cancer. Oncol Lett, 2017, 14(5):5753-5758.
[4] Cong WM, Wu MC. New insights into molecular diagnostic pathology of primary liver cancer: Advances and challenges. Cancer Lett, 2015, 368(1):14-19.
[5] Gabriel M, Tomczak J, Snochziókiewicz M, et al. Superb micro-vascular imaging (SMI): a Doppler ultrasound technique with potential to identify, classify, and follow up endoleaks in patients after endovascular aneurysm repair (EVAR). Abdom Radiol, 2018, 43(12):3479-3486.
[6] 中华人民共和国卫生部. 原发性肝癌诊疗规范(2011年版). 中华肝脏病杂志, 2012, 20(6):929-946.
[7] Karavias D, Kourea H, Sotiriadi A, et al. Gangrenous cholecystitis related to transcatheter arterial chemoembolization (TACE) treatment for hepatocellular carcinoma.J Gastrointest Surg, 2015, 19(11):2093-2095.
[8] Huang W, You L, Yang S, et al. Metronomic S-1 chemotherapy plus transcatheter arterial chemoembolization (TACE): a promising treatment of hepatocellular carcinoma refractory to TACE. J Buon, 2016, 21(4):909-916.
[9] Ha TY, Hwang S, Lee YJ, et al. Absence of benefit of transcatheter arterial chemoembolization (TACE) in patients with resectable solitary hepatocellular carcinoma.World J Surg, 2015, 40(5):1200-1210.
[10] Ai N, Liu W, Li ZG, et al. High expression of GP73 in primary hepatocellular carcinoma and its function in the assessment of transcatheter arterial chemoembolization.Oncol Lett, 2017, 14(4):3953-3958.
[11] Maki S, Konno T, Maeda H. Image enhancement in computerized tomography for sensitive diagnosis of liver cancer and semiquantitation of tumor selective drug targeting with oily contrast medium. Cancer, 2015, 56(4):751-757.
[12] Yang K, Cheng YS, Yang JJ, et al. Primary hepatic neuroendocrine tumors: multi-modal imaging features with pathological correlations.Cancer Imaging, 2017, 17(1):20-26.
[13] Dong Y, Zhu Z, Wang WP, et al. Ultrasound features of hepatocellular adenoma and the additional value of contrast-enhanced ultrasound. Hepatobiliary Pancreat Dis Int, 2016, 15(1):48-54.
[14] Park AY, Seo BK, Cha SH, et al. An innovative ultrasoundtechnique for evaluation of tumor vascularity in breast cancers: superb micro-vascular imaging. J Breast Cancer, 2016, 19(2):210-213.
[15] 刘水清, 马一博, 韩宗宏, 等. 超微细血流成像技术评价肝癌介入治疗疗效的价值. 中华肝脏病杂志, 2017, 25(7):512-516.
[16] Kong SH, Yue XW, Kong S, et al. Application of contrast-enhanced ultrasound and enhanced CT in diagnosis of liver cancer and evaluation of radiofrequency ablation.Oncol Lett, 2018, 16(2):2434-2438.
[17] Durmaz MS, Sivri M. Comparison of superb micro-vascular imaging (SMI) and conventional Doppler imaging techniques for evaluating testicular blood flow.J Med Ultrason, 2018, 45(3):443-452.
[18] 杨志军, 赵丽娟. 超声超微细彩色血管成像技术评价经肝动脉化疗栓塞治疗的原发性肝癌患者肿瘤血供效能初步应用研究. 实用肝脏病杂志, 2018, 21(4):509-512.
[19] Lee DH, Lee JY, Han JK. Superb microvascular imaging technology for ultrasound examinations: Initial experiences for hepatic tumors. Eur J Radiol, 2016, 85(11):2090-2095.
[20] Liao M, Zhu Z, Wang H, et al. Adjuvant transarterial chemoembolization for patients after curative resection of hepatocellular carcinoma: a meta-analysis. Scand J Gastroenterol, 2017, 52(6):624-634.

Detection of tumor foci blood supply by SMI, CDFI and enhanced CT in patients with primary liver cancer after TACE

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	Ma Ning, Dai Xiaowen , Wu Jianjiang. Influence of different types of liquid infusion on clinical efficacy and safety of patients withhepatocellular carcinoma undergoing partial hepatectomy [J]. Journal of Practical Hepatology, 2020, 23(1): 102-105.
[2]	Xu Ling, Ren Feng. Roles ofhepatic macrophages in several common liver diseases [J]. Journal of Practical Hepatology, 2020, 23(1): 145-148.
[3]	Liu Xing, Zhao Shuli, Zhang Dianlong. Effect of sevoflurane inhalation on hepatic ischemia-reperfusion injury in patients with primary liver cancer undergoing partial hepatectomy [J]. Journal of Practical Hepatology, 2019, 22(5): 728-731.
[4]	Zhang Zhicheng, Yuan Guangqi, Mo Chanjun. Impact of blood supply on efficacy of hepatic artery embolization in treatment of patients with hepatic hemangioma [J]. Journal of Practical Hepatology, 2019, 22(5): 736-739.
[5]	Pei Ying, Huang Feng, Yin Hongzhen, et al. Preliminary study on intestinal microecology in mice with xenograft hepatoma intervened by sodiumnorcantharidate [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(4): 486-489.
[6]	Dai Qingyun, Wang Rundong, Jia Weidong. Prediction of early tumor recurrence by predictive nutritional index in patients with hepatocellular carcinoma undergoing hepatectomy [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(4): 561-564.
[7]	Cui Faqiang, Li Tao, Wang Zheng, et al. A pilot study on cetuximab and KRAS gene mutation in treatment of patients with primary liver cancer [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(4): 565-568.
[8]	Yang Fucun, Shang Huaixue, Gai Yonghao. Enhanced magnetic resonance imaging by gadolinium disodium sebacate in diagnosis of patients with focal liver lesions [J]. Journal of Practical Hepatology, 2019, 22(4): 577-580.
[9]	Peng Xinjian, Xiao Yuhui, Xu Siding. Diagnostic value of diffusion-weighted magnetic resonance imaging in patients with radiation-induced liver injury with underlying hepatocelullar carcinoma [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(3): 373-376.
[10]	Zhao Xiaoguang, Shi Yujie. Protective effect of reduced glutathione on liver function in patients with advanced primary liver cancer underwent transarterial chemoembolization [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(3): 425-428.
[11]	Li Ketian, Shen Mingge, Wang Fengrong, Hu Chunrong, Cao Yujie, Lu Peng. Impact of blood glucose levels on imaging quality of PET/CT examination in patients with primary liver cancer [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(2): 256-259.
[12]	Wang Xiuqing, Ma Yanjun, Zhan Jinli. Efficacy of transcatheter arterial chemoembolization and ultrasound-guided microwave ablation in the treatment of patients with hepatocellular carcinoma at special sites [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(2): 260-263.
[13]	Zhang Bangjian, Wei Shoucun, Yang Xiaoyan. Effects of dexmedetomidine combined with propofol anesthesia on perioperative stress response and postoperative recovery quality in patients undergoing hepatectomy [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(2): 264-267.
[14]	Zhang Xiaozhou, Shuai Ling, Wang Qingda, Yang Nan. Changes of serum miR-335 levels in patients with hepatocellular carcinoma undergoing transcatheter arterial chemoembolization [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(2): 268-271.
[15]	Xu Dafeng, Zhou Kailun, Li Zhuori, et al.. Preliminary observation of miR-144 liposomes on inhibition of proliferation, migration and invasion of liver cancer cells in vitro and in vivo [J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2019, 22(1): 25-28.