Abstract: Objective To summarize the clinical and laboratory characteristics of patients with drug-induced liver injury（DILI）. Methods 21 patients with DILI were recruited in our hospital between March 2015 and October 2016,and all the patients received methylprednisolone and 13 were followed-up for 3 to 16 months. Results Out of the 21 patients,6 were men and 15 women with an average age of（49.3±15.2） years;12 cases were diagnosed as acute DILI,and 9 as chronic;serum autoantibodies were positive in 17（81.0%） cases;liver biopsies were performed in 15 patients with DILI,and the average score of autoimmune hepatitis （AIH） was （3.9±1.2） points;serum biochemical parameters improved after glucocorticoid therapy at the dose of （0.65±0.15） mg·kg^-1·d^-1;white blood cell counts significantly increased after steroid therapy,but no complications occurred in this series;Out of 13 patients followed-up,7 relapsed after discontinuation of corticosteroids. Conclusion Glucocorticoids might be administered in patients who poorly respond to conventional therapy,especially in those with serum autoantibodies positive. But the discontinuation of steroid might lead to the relapse of illness,which needs further investigations.

Key words: Drug-induced liver injury, Antinuclear antibody, Glucocorticoid, Therapy