内质网应激与肝纤维化关系研究进展*

doi:10.3969/j.issn.1672-5069.2018.06.041

Abstract

Abstract: The prevention and treatment of hepatic fibrosis（HF） is a major medical challenge worldwide.The activation of hepaticstellate cells （HSCs） and the excess deposition of extracellular matrix （ECM） are believed to play an important role in the development of HF.More and more researches have verified that endoplasmic reticulum stress （ERS） is involved in the development and reversion of HF. This review will discuss the effects of ERS on HF and explore new insights for the prevention and treatment of HF.

Key words: Hepatic fibrosis, Endoplasmic reticulum stress, Hepatic stellate cell

Pan Gaofeng, Fu Maoying, Gao Yufeng.. Endoplasmic reticulum stress in pathogenesis of hepatic fibrosis[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2018, 21(6): 987-990.

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Endoplasmic reticulum stress in pathogenesis of hepatic fibrosis

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