葡萄糖调节蛋白78在非酒精性脂肪性肝病发病中的作用*

doi:10.3969/j.issn.1672-5069.2018.02.046

Abstract

Abstract: Glucose regulated protein 78 （GRP78） is regarded as a major chaperone of endoplasmic reticulum （ER）,which plays an important role in the process of protein folding and transport as well as endoplasmic reticulum stress. In addition,it also exists in the surface of tumor cells,endothelial cells and monocytes,and serves as a receptor for viral entry into host cells. ER stress is an important pathogenesis of nonalcoholic fatty liver disease（NAFLD）. The excavation of GRP78’s function will provide a new approach for the defense mechanism of NAFLD.

Key words: Nonalcoholic fatty liver disease, Glucose regulated protein 78, Endoplasmic reticulum stress

Wang Lan, Yang Yunmei. Role of glucose regulated protein 78 in the pathogenesis of nonalcoholic fatty liver disease[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2018, 21(2): 309-312.

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Role of glucose regulated protein 78 in the pathogenesis of nonalcoholic fatty liver disease

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