Abstract: Objective To investigate the protective effect of combination of ulinastatin with magnesium isoglycyrrhizinate and reduced glutathione on hepatic functions in patients with primary liver cancer after partial hepatectomy. Methods 78 patients with primary liver cancer were included in our hospital between February 2013 and October 2016,and they received partial hepatectomy. After operation,the patients were randomly divided into group B,receiving combination of ulinastatin,magnesium isoglycyrrhizinate and reduced glutathione,and group A,receiving magnesium isoglycyrrhizinate and reduced glutathione. Serum tumor necrosis factor （TNF）-α,interleukin （IL）-6 and C reactive protein（CRP） levels were detected by ELISA. Results There was no significant differences between the two groups as respect to the indexes of liver functions and serum inflammatory factors before operation（P>0.05）;serum alanine aminotransferase （ALT） level in group B seven days after operation were significantly lower than in group A （P<0.05）;at the end of seven days,serum CRP,TNF-α and IL-6 levels in group B were （17.2±2.7） mg/L,（2.7±0.6） pg/ml and （28.4±5.7） pg/ml,much lower than [（19.8±3.2） mg/L,（3.5±0.7） pg/ml and （33.4±6.2） pg/ml in group A,P<0.05],and at the end of 14 d,serum CRP,TNF-α and IL-6 levels in group B were（13.6±3.0） mg/L,（2.0±0.4） pg/ml and （20.5±4.7） pg/ml,much lower than[（16.3±3.5） mg/L,（2.8±0.6） pg/ml and（24.6±4.9）pg/ml in group A,P<0.05];there was no significant differences of the incidences of postoperative septal effusion,bile leakage and death between the two groups （P>0.05）,while the incidence of hepatic failure in group B was significantly lower than that in group A （2.5% vs. 21.1%,P<0.05）. Conclusion Combination of ulinastatin,magnesium isoglycyrrhizinate and reduced glutathionecan might enhance the protective effects on hepatic function in patients with primary liver cancer after partial hepatectomy.

Key words: Hepatoma, Partial hepatectomy, Ulinastatin, Liver functions