Abstract: Objective To investigate the safety and efficacy of percutaneous transhepatic intrahepatic portosystemic shunt（PTIPS） in management of patients with portal thrombosis after splenectomy. Methods Thirty patients with portal thrombosis after splenectomy were recruited in our hospital between January 2011 and December 2015. All patients received PTIPS,checked-up by CT scan and followed-up for（22.1±3.8） m. Results The success rate of the operation was 90%（27/30）,and 3 patients failed to opening their portal vein occlusion during operation. No serious complications such as surgical related death were found in this series. The portal-systemic pressure gradient decreased from （21.5±3.4） mmHg to （13±2.8） mmHg in the 27 patients with successful operation. During the follow-up period, 4 patients（13.3%） got the shunt stent occlusion,and repatency by balloon dilatation and a new stent placed instead. 2 patients（6.7%） had hepatic encephalopathy within 1 months after the operation,and were improved after appropriate treatment. 5（16.7%） patients died of hepatic failure or cerebral hemorrhage. Conclusion The application of PTIPS in the management of patients with portal thrombosis after splenectomy is effective,and the procedure is feasible and safe. Further study is still needed in the future to get the indications of this operation.

Key words: Splenectomy, Portal thrombus, Percutaneous transhepatic intrahepatic portosystemic shunt, Efficacy