Abstract: Objective To investigate the clinical application of enhanced recovery after surgery （ERAS） program in patients with portal hypertention underwent pericardial devascularization with splenectomy. Methods Eighty patients with portal hypertension were recruited in our hospital in recent two years,and they were randomly divided into two groups. Forty patients underwent ERAS management during the perioperative period,and another forty patients underwent conventional perioperative treatment as control groups. Results The pain score 24 h and 48 h postoperation in the ERAS group were （2.1±0.6） and （2.2±0.6）,much lower than （3.7±0.8） and （3.0±0.6） in the control（P<0.01）;the postoperative anal exhaust time,extubation time and hospital stay in the ERAS group were （2.4±0.5） d,（5.2±0.8） d and （8.5±2.2） d,much shorter than （3.5±0.7） d,（7.6±3.0） d and （11.6±5.3） d in the control（P<0.01）;serum alanine transaminase,total bilirubin and albumin levels 5 day after surgery were（27.6±11.3） U/L,（18.3±6.2） μmol/L and （41.8±5.4） g/L,while they were [（48.6±44.3） U/L,（23.3±11.5） μmol/l and （37.1±5.1） g/L,respectively,significantly different between the two groups（P<0.01）;there were 19 cases （47.5%） having complications after operation in the ERAS group,much lower than 29 cases（72.5%） in the control group（P<0.05）. Conclusion ERAS in the perioperative management of patients with portal hypertension is effective and safe,which might accelerate the recovery of patients.

Key words: Portal hypertension, Enhanced recovery after surgery, Splenectomy, Pericardial devascularization, Recovery