Abstract: Objective To investigate the evaluation of left ventricular systolic function by three-dimensional speckle tracking imaging（3D-STI） in patients with liver cirrhosis. Methods 68 patients with viral hepatitis liver cirrhosis and 30 healthy persons were recruited in this study,and ultrasound was performed. Left ventricular end diastolic diameter （LVEDD）,left ventricular end-diastolic diameter （LVESD）,left ventricular end-diastolic volume （LVEDV）,left ventricular end-systolic volume （LVESV）,ejection fraction（LVEF） were routinely measured, and the systolic peak strain of different parts of myocardium was assayed by 3D-STI.The LVEDD,LVESD,LVEDV,LVESV,LVEF,the systolic peak strain at the basal segment,middle segment,apical segment,and apex cap between patients with liver cirrhosis and healthy control were compared. The predictive value of systolic peak strain of the parameters on the prognosis of the patients was evaluated by ROC prediction model. Results The levels of LVEDV and LVESV in patients with liver cirrhosis [（122.7±16.3）ml and （46.2±6.2）ml] were significantly higher than[（102.6±12.2）ml and（35.3±5.2）ml,P<0.001] in healthy persons,while there were no significant differences between the levels of LVEDD,LVESD and LVEF in patients with liver cirrhosis and healthy control（P>0.05）; the peak systolic peak of basal segment,middle segment,apical segment and apex cap in cirrhotics [（18.8±4.3）,（19.2±4.2）,（18.6±3.5）,（19.2±4.1）] were much lower than[（21.3±5.2）,（23.8±3.9）,（22.4±4.1）,（23.9±4.3）,P<0.001] in the healthy person; during the follow-up period, 21 died and 3 lost. The ROC curves showed that the area under ROC by the systolic peak of the basal segment,middle segment,apical segment and apex cap were 0.857,0.893,0.869 and 0.866,the strain was 18.85,20.05,16.25,18.05,and the sensitivity were 78.6%,69.0%,85.7% and 74.7%,and the specificity were 82.0%,91.0%,66.7% and 84.5%,respectively. Conclusion The patients with liver cirrhosis tends to have left ventricular systolic dysfunction. The 3D-STI is an alternative approach to evaluate the left ventricular systolic dysfunction at early stage non-invasively.

Key words: Liver cirrhosis, Left ventricular systolic function, Three-dimensional spot tracing, Prognosis