Abstract: Objective To investigate the risk factors for significant liver fibrosis in patients with chronic hepatitis B. Methods 80 patients with chronic hepatitis B were recruited in our hospital between January 2015 and August 2016，and all patients underwent liver biopsy. Significant liver fibrosis was defined as fibrosis stage equal to or greater than S2. Serum HBV DNA levels，HBV markers，liver function indexes，routine blood and coagulation function indexes were assayed. Results 58 patients （72.50%） were found having significant liver fibrosis in this series；In patients with significant liver fibrosis，serum HBV DNA，alanine aminotransferase （ALT）， aspartate aminotransferase （AST），gamma-glutamyl transferase （GGT），prothrombin time （PT），red blood cell volume distribution width （RDW） and mean platelet volume （MPV） levels were （9.32±1.20） log10 IU/ml， （49.50±12.48） U/L，（48.91±10.11） U/L，（60.38±21.21） U/L，（15.52±1.28） s，（15.51±2.33） % and （12.20±3.05） fl，significant higher than those in 22 patients without significant liver fibrosis[（6.49±1.18） log10 IU/ml，（31.29±8.50） U/L，（28.47±6.77） U/L，（26.35±17.49） U/L，（14.10±2.31） s，（13.29±3.20） % and（10.13±3.22） fl，respectively，P<0.05]；White blood cell （WBC） counts，hemoglobin （Hb） and platelet （PLT） counts were（5.10±1.73）×10⁹/L，（123.47±12.10） g/L and（120.76±20.85）×10⁹/L，much lower than those in patients without significant liver fibrosis [（6.51±1.52）×10⁹/L，（130.85±13.10） g/L，（213.75±23.48）×10⁹/L，respectively，P<0.05]；HBV DNA， ALT， AST，GGT，PT，RDW and MPV were correlated positively with liver fibrosis stages （r=0.642，r=0.411， r=0.411，r=0.447，r=0.397，r=0.538 and r=0.486，P<0.05），while WBC，Hb and PLT were correlated negatively with liver fibrosis stages （r=-0.375，r=-0.362 and r=-0.543，P<0.05）; The regression analysis revealed that decreased PLT counts （OR=0.93，P<0.05） was significantly associated with significant liver fibrosis. Conclusion Abnormal blood cell counts and liver function indexes hints a higher risk of liver fibrosis in patients with chronic hepatitis B.

Key words: Hepatitis B, Liver fibrosis, Risk factors, Regression analysis