Abstract: Objective To investigate the changes of blood coagulation function parameters after plasma perfusion in patients with liver failure. Methods 60 patients with liver failure were enrolled in this study between January 2014 and June 2015. All patients received plasma perfusion at the base of conventional supporting treatment. 1 to 4 plasma perfusions were conducted in each patients according to their own disease circumstance. Coagulation function indexes，including blood PTA，APTT，INR，FIB，TT，peripheral blood PLT counts and D-dimer，before the first plasma perfusion as well as 1 h and 2 h after plasma perfusion were recorded and compared. Results Blood PTA，APTT，INR，FIB and TT levels after plasma perfusion 1 h and 2 h had no difference with those before the plasma perfusion [PTA（28.41±3.09） % 1 h，（29.73±3.13） % 2 h vs. （28.57±3.17）% before；APTT （32.79±5.80） s 1 h，（31.05±5.62） s 2 h vs. （32.68±5.75） s before；INR（1.73±0.69） 1 h，（1.61±0.65） 2 h vs. （1.69±0.65） before；FIB （3.15±0.90） g/L 1 h，（3.25±0.91） g/L 2 h vs. （3.18±0.92） g/L before and TT （15.29±4.10） g/L 1 h，（14.86±4.12） g/L 2 h vs. （15.24±4.13） s before]；However，peripheral blood PLT counts and D-dimer levels after plasma perfusion 1 h and 2 h were significantly different from those before plasma perfusion[PLT count （101.59±24.92）×10⁹/L 1 h，（119.84±25.16）×10⁹/L 2 h vs. （185.43±31.0）×10⁹/L before；D-dimer（1.63±0.29） mg/L 1 h，（1.75±0.30） mg/L 2 h vs.（0.67±0.25） mg/L before，P<0.05]. Conclusion Plasma perfusion can absorb harmful substances in blood as a therapeutic approach for patients with liver failure，but we should take it into consideration that this therapy might reduce the platelet counts and interfere with the fibrinolytic function.

Key words: Liver failure, Plasma perfusion, Coagulation function