Abstract: Objective To study the effect of IGF-1 on intestinal mucous injury in mice with alcohol-induced liver disease and to observe the impact of glutamine on expression of IGF-1. Methods Thirty c57 mice were randomly divided into control,model and intervention group（10 in each）. The control group were fed with Lieber Decarli liquid without ethanol,and mice in the model and intervention group were fed with 4% ethanol Lieber Decarli liquid. At the same time,glutamine was given to the mice in the intervention group. The serum endotoxin was examined after 12 weeks,and intestinal tissues were assessed with HE staining and the expression of IGF-1 in intestine was detected by immunohistochemical method. Results The serum endotoxin in the model group was much higher than that in control group（0.38±0.05 Eu/L vs. 0.13±0.02 Eu/L,P<0.05）,while it decreased in intervention group as compared with the model group;the histopathological score of colon injury in the model group was much higher than that in control group（10.3±1.3 vs 4.8±1.2,P<0.05）;the expression of IGF in the model group was much higher than that in control group（2.3±0.2 vs. 0.9±0.2,P<0.05）. Conclusion Alcoholic liver disease is always complicated with intestinal mucous injury. IGF-1 might play a role in alcoholic liver disease. Glutamine can protect the intestinal mucosa,and it may be associated with the expression of IGF-1.

Key words: Alcohol liver disease, Intestinal mucous injury, IGF-1, Mice