Abstract: Objective To study the pathological changes of hepatic sinusoids in patients with chronic hepatitis B. Methods The number,total area,total perimeter and average diameter of hepatic sinusoids were detected by stereology under transmission electron microscope. Results The total area,total perimeter and average diameter of hepatic sinusoids in patients with chronic hepatitis B of severe degree increased,the basal lamina formed,and collagen deposited in Disse's space;WP bodies were detected in 53.5% and 59.1% in SECs in patients with CHB of mild and moderate degree,respectively,while that was only in 12.9% of patients with CHB of severe degree. Conclusion The pathological changes of hepatic sinusoids play a key role in the microcirculation disturbance of liver in patients with chronic hepatitis B.

Key words: Hepatitis B, Hepatic sinusoids, Stereology, Sinusoidal endothelial cell