Abstract: Objective To investigate the relationship between non-alcoholic fatty liver disease （NAFLD） and different histological types of primary bronchogenic carcinoma（lung cancer）. Methods In-patients with primary lung cancer，who had Results of liver ultrasound check-up in Shanghai Pulmonary Hospital in 2009 and in 2013，were restrospectively enrolled in this study，and we tried to explore the relationship of NAFLD to what histological types of lung cancer. Results Among 3664 patients with lung cancer recruted in the two years，807 patients （22.0%） was found to have NAFLD，1379 （37.6%） was female，and 2189 （59.74%） was of adenocarcinoma；The percentage of female，adenocarcinoma，and NAFLD in 2607 patients with lung cancer presented in 2013 were significantly higher than those in 1057 patients met in 2009（40.0% vs. 31.8%，67.8% vs. 40.2%，and 18.6% vs. 23.4，all P<0.001）；In addition，the prevalence of NAFLD in patients with adenocarcinoma （545/2189，24.9 %） was significantly higher than that in squamous cell carcinoma （150/898，16.7%，P<0.01） or small cell lung cancer （16/86，18.6%，P<0.001） patients；NAFLD （OR 1.281，95% CI 1.025-1.600） and obesity（OR 1.391，95% CI 1.135-1.704） were independently positively，while male （OR 0.259，95%CI 0.208-0.323） and smoking （OR 0.588，95%CI 0.486-0.712） were negatively correlated to adenocarcinoma of lung cancer by multiple regression analysis. Conclusions Adenocarcinoma is becoming the most common histological type of lung cancer，and NAFLD is common in patients with pulmonary adenocarcinoma. Obesity and NAFLD might be associated with increased incidence of lung cancer of this type.

Key words: Non-alcoholic fatty liver disease, Lung cancer, Pulmonary adenocarcinoma, Obesity