Abstract: Objective The aim of this study was to summarize the clinical features of patients with hepatitis B liver cirrhosis (LC) complicated by esophagogastric variceal bleeding (EVB), and to explore the risk factors of EVB. Methods The clinical data of 108 patients with hepatitis B LC complicated with gastroesophageal varices (GOV) were collected in our hospital between June 2018 and June 2020, and internal medicine was given when the EVB occurred. The clinical features of patients were summarized and the independent risk factors of EVB were evaluated by univariate and multivariate Logistic regression analysis. Results Among the 108 patients with hepatitis B LC and GOV, the EVB occurred in 38 cases (35.2%) , and out of which, 5 patients (13.2%) died within 72 hours after onset of bleeding; the univariate analysis indicated that overwork was not significantly related with EVB in patients with hepatitis B LC and GOV (P>0.05), while improper diet, taking non-steroidal anti-inflammatory agents, platelet (PLT) count, prothrombin time (PT), serum albumin (ALB), diameter of portal vein and splenic vein, red-color sign, Child-Pugh class of liver functions and GOV degrees were significantly correlated with EVB happening (P<0.05); the multivariate Logistic regression analysis showed that improper diet [OR(95%CI) : 2.2 (1.3-3.7)], increased portal vein diameter [OR(95% CI:1.4(1.1-1.7)], prolonged PT [OR(95% CI:1.3(1.1-1.6)], red-color sign [OR(95% CI:3.3(1.6-7.1)], Child-Pugh class C [OR(95% CI:3.9(1.7-9.0)] and severe GOV [OR(95% CI:3.5(1.9-6.5)] were the independent risk factors of EVB in patients with LC. Conclusion The EVB is the improper cause of gastrointestinal bleeding in patients with hepatitis B-induced LC,and the common intriguing events should be dealt with early and appropriately in clinical practice to decrease the EVB occurrence.

Key words: Liver cirrhosis, Gastroesophageal varices, Esophagogastric variceal bleeding, Risk factors