酒精性肝硬化患者临床特征分析

doi:10.3969/j.issn.1672-5069.2021.03.027

Abstract

Abstract: Objective The aim of this study was to summarize the clinical features of patients with alcoholic liver cirrhosis (ALC).Methods A total of 87 patients with ALC and 96 with hepatitis B liver cirrhosis (LC) were admitted to our hospital between June 2016 and June 2019. All patients underwent sonography and peripheral blood neutrophil/lymphocyte count ratio (NLR)] were detected by full-automatic biochemical analyzer.Results The proportion rate of male patients with ALC was 86.2%, significantly higher than 70.8% in patients with LC (P<0.05); the incidences of fatigue and anorexia, ocular spider and facial telanqiectasis in patients with ALC were 79.3%, 43.7% and 28.7%, significantly higher than 56.3%, 25.0% and 3.1% in patients with LC (P<0.05), while the Child-Pugh class was superior to that in patients with LC (P<0.05); the incidences of complications such as GI bleeding and infections in patients with ALC were much lower in patients with LC (P<0.05); the white blood cell count and NLR in patients with ALC were (6.2±1.6)×10⁹/L and NLR为(3.5±2.8), significantly higher than [(4.9±1.3)×10⁹/L and (2.6±1.9), P<0.05] in patients with LC; serum bilirubin and alanine aminotrasaminase levels in patients with ALC were significantly lower than those in patients with LC, while serum glutamyl transpeptidase and alkaline phosphatase levels were (296.5±22.7)U/L and (249.6±48.2)U/L, significantly higher than those in patients with LC [(124.4±25.8)U/L and (116.7±30.2)U/L, respectively, P<0.05]; the proportion of liver enlargement and echo enhancement of liver parenchyma in patients with ALC were 36.8% and 86.2%, significantly higher than 12.5% and 52.1% (P<0.05), while liver capsule serration and heterogeneous echo of liver parenchyma were 26.4% and 19.5%, significantly lower than 75.0% and 55.2% (P<0.05) in patients with LC. Conclusion The patients with ALC has unique clinical feature, which might guide the clinicians to take an appropriate measures dealing with them in clinical practice.

Key words: Alcoholic liver cirrhosis, Clinical feature, Neutrophil/lymphocyte count ratio

Li Hua, Wen Jianghua, Wu Yingchun, et al. Clinical features of patients with alcoholic cirrhosis[J]. Journal of Practical Hepatology, 2021, 24(3): 411-414.

References

[1] Kodali S, Kaif M, Tariq R, et al. Alcohol relapse after liver transplantation for alcoholic cirrhosis-impact on liver graft and patient survival: a meta-analysis. Alcohol, 2018,53(2):166-172.
[2]Sabath BF, Khan S. A 54-year-old woman with a history of alcoholic cirrhosis and recurrent ascites presenting with abdominal pain and increasing abdominal girth. Chest, 2020,157(3):95-97.
[3] Savi, Vra ari V, Mili N, et al. Vitamin D supplementation in patients with alcoholic liver cirrhosis: a prospective study. Minerva Med, 2018, 109(5):352-357.
[4] 张冰, 解学军. 酒精性肝硬化患者血CTLA-4和PNPLA3基因多态性及其临床意义分析. 实用肝脏病杂志, 2020, 23(1):86-89.
[5] Ganne-Carrié N, Chaffaut C, Bourcier V, et al. Estimate of hepatocellular carcinoma incidence in patients with alcoholic cirrhosis. J Hepatol, 2018, 69(6):1274-1283.
[6] 张潇潇, 杨杨, 赵文, 等. 肝硬化合并细菌性肺炎的危险因素及其预后分析. 中华肝脏病杂志, 2020,28(7):561-566.
[7] Ohashi K, Pimienta M, Seki E. Alcoholic liver disease: a current molecular and clinical perspective. Liver Res, 2018, 2(4):161-172.
[8] Petta S, Sebastiani G, Bugianesi E, et al. Non-invasive prediction of esophageal varices by stiffness and platelet in non-alcoholic fatty liver disease cirrhosis. J Hepatol, 2018, 69(4):878-885.
[9] 高慧, 匡哲, 钟春秀, 等. 接受抗病毒治疗的慢性乙型肝炎患者非酒精性脂肪性肝病的患病率及其危险因素分析. 中华肝脏病杂志, 2019, 27(5):347-351.
[10] Otete H, Deleuran T, Fleming KM, et al. Hip fracture risk in patients with alcoholic cirrhosis: a population-based study usingEnglish and Danish data. J Hepatol, 2018, 69(3):697-704.
[11] 中华医学会肝病学分会脂肪肝和酒精性肝病学组, 中国医师协会脂肪性肝病专家委员会. 酒精性肝病防治指南(2018更新版). 实用肝脏病杂志, 2018, 21(2):170-176.
[12] 中华医学会肝病学分会.肝硬化腹水及相关并发症的诊疗指南. 实用肝脏病杂志, 2018, 21(1):21-31.
[13] Mellinger JL, Shedden K, Winder GS, et al. The high burden of alcoholic cirrhosis in privately insured persons in theUnited States. Hepatology, 2018, 68(3):872-882.
[14] Lin SY, Lin CL, Chen WS, et al. Association between alcoholic cirrhosis and hemorrhagic stroke: a nationwide population-based study. Alcohol, 2019, 54(3):302-309.
[15] Strnad P, Buch S, Hamesch K, et al. Heterozygous carriage of the alpha1-antitrypsin Pi*Z variant increases the risk to develop liver cirrhosis. Gut, 2019, 68(6):1099-1107.
[16] 周小兵,李玉鑫,高方媛, 等. 肝硬化合并自发性细菌性腹膜炎133例的危险因素分析. 中华消化杂志, 2019, 39(4):268-270.
[17] Gustot T, Jalan R. Acute-on-chronic liver failure in patients with alcohol-related liver disease. J Hepatol, 2019, 70(2):319-327.
[18] Bezinover D, Dirkmann D, Findlay J, et al. Perioperative coagulation management in liver transplant recipients. Transplantation, 2018,102(4):578-592.
[19] Intagliata NM, Argo CK, Stine JG, et al. Concepts and controversies in haemostasis and thrombosis associated with liver disease: proceedings of the 7th international coagulation in liver disease conference. Thromb Haemost, 2018, 118(8):1491-1506.
[20] Dhanda AD, Sinha A, Hunt V,et al. Infection does not increase long-term mortality in patients with acute severe alcoholic hepatitis treated with corticosteroids. World J Gastroenterol, 2017,23(11):2052-2059.
[21] Lee BP, Im GY, Rice JP, et al. Underestimation of liver transplantation for alcoholic hepatitis in the national transplant database. Liver Transpl, 2019,25(5):706-711.

Clinical features of patients with alcoholic cirrhosis

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