Abstract: Objective The aim of this study was to explore the clinical feature and impacting factors of esophageal and gastric variceal bleeding in patients with hepatitis B-induced liver cirrhosis (LC).Methods The clinical materials in 90 patients with hepatitis B cirrhosis and esophageal and gastric variceal bleeding and in 90 hepatitis with hepatitis B liver cirrhosis and varices were retrospectively analyzed. The impacting factors of variceal bleeding were analyzed by univariate multivariate Logistic regression.Results The univariate analysis showed that the long course of cirrhosis, history of variceal bleeding, the application of non-steroidal drugs, poor Child-Pugh class, the severity of esophageal varices, the widen diameter of left gastric vein and portal vein, the prolonged PT, ascite and low serum albumin level were significantly different between the two groups (P<0.05); the multivariate Logistic regression analysis showed that the long course of cirrhosis, non-steroidal administration, poor Child-Pugh class, the severity of esophageal varices, the widen diameter of left gastric vein and portal vein, the prolonged PT and ascite were the independent risk factors for esophageal varices bleeding in patients with liver cirrhosis (OR=3.145; 3.171; 2.190; 2.672; 2.363; 3.142; 3.083; 3.062, P<0.05), while .the high serum albumin level was a protective factor for varices bleeding (OR=0.288, P<0.05).Conclusion Some factors might lead to the esophageal and gastric varices bleeding in patients with hepatitis B liver cirrhosis, which should be paid more attention to and dealing with promptly in clinical practice.

Key words: Liver cirrhosis, Esophageal and gastric variceal bleeding, Clinical features, Risk factors