Abstract: Objective The aim of this study was to investigate the clinical value of serum pentraxin 3 (PTX3) and soluble tumor necrosis factor-like weak inducer of apoptosis (TWEAK) levels in predicting death of patients with decompensated hepatitis B cirrhosis.Methods 108 patients with decompensated hepatitis B-induced liver cirrhosis were admitted to our hospital between January 2016 and June 2019, and all were followed-up for 6 months. The protein-energy wasting (PEW) was evaluated, and serum tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and C-reactive protein (CRP) as well as serum PTX3 and sTWEAK levels were detected.Results 39 patients with decompensated hepatitis B-induced liver cirrhosis out of our series died, and 69 survived during six month follow-up period; serum TNF-α, IL-6, CRP, PTX3 and sTWEAK levels in dead group at presentation were significantly higher than those in the survival group[(68.3±11.2)ng/L vs. (39.8±19.0)ng/L, (918.3±148.7)ng/L vs. (249.6±51.2)ng/L, (5.6±0.3)mg/L vs. (2.4±0.9)mg/L, (19.7±3.3)ng/mL vs. (11.6±0.6)ng/mL, and (1459.0±215.3)ng/L vs. (549.5±23.5)ng/L, respectively, all P<0.05], while the SGNA score in the dead group was significantly lower than that in the survival group[(16.5±8.6) vs. (23.2±7.6), P<0.05]; the multivariate Logistic analysis showed that the SGNA, serum PTX3 and sTWEAK levels were the independent risk factors for death in patients with decompensated hepatitis B cirrhosis (OR=1.366, 95%CI:1.036-1.801; OR=1.939, 95%CI:1.409-2.670, OR=2.891; 95%CI:1.909-4.380, P<0.05); the SGNA, serum PTX3 and sTWEAK levels had predictive value for the death of patients with decompensated hepatitis B cirrhosis with the area under ROC (AUC) of serum PTX3 level the largest(AUC=0.868, 95%CI:0.823-0.912), of serum sTWEAK the relative large(AUC=0.753, 95%CI:0.690-0.816)and the SGNA smallest (AUC=0.675, 95%CI:0.606-0.743), and the sensitivity and specificity of serum PTX3 level were the highest, 83.52% and 74.16%, respectively.Conclusion Serum levels of PTX3 and sTWEAK in dead patients with decompensated cirrhosis elevate early, and the determination of them might help predict the prognosis of patients with decompensated hepatitis B cirrhosis in the early stage, which is worthy of clinical verification.

Key words: Liver cirrhosis, Pentraxin 3, Soluble tumor necrosis factor-like weak inducer of apoptosis, Prognosis