Abstract: Objective The aim of this study was to investigate the efficacy of ultrasound-guided percutaneous transhepatic cholangiography (PTCD) in the treatment of patients with acute obstructive suppurative cholangitis ((AOSC). Methods 78 patients with AOSC were recruited in our hospital between March 2015 and November 2018, and were randomly divided into control (n=39) and observation group (n=39) . The patients in the control group were treated with conventional laparotomy, and those in the observation group were treated with ultrasound-guided PTCD. Results The operative time, the amount of bleeding, the time of indwelling drainage tube and the hospital stay in PTCD-treated patients were (89.7±7.5) min, (26.3±2.4) ml, (8.8±1.0) d and (9.7±1.5) d, significantly less or shorter than in the control; After treatment, serum levels of procalcitonin, interleukin-6, interleukin-4 and C-reactive protein in the observation group were (5.9±0.8) ng/L, (87.8±7.4) ng/L, (14.7±1.5) ng/L and (2.1±0.5) mg/L, significantly lower than in the control; the complication rate in the observation group was significantly lower than that in the control group (5.1% vs. 23.1%, P<0.05). Conclusion Ultrasound guided PTCD treatment of patients with AOSC is efficacious, which effectively improve the surgery-related indexes and reduce complications, which might be related to mild inflammatory reaction.

Key words: Acute obstructive suppurative cholangitis, Percutaneous transhepatic biliary drainage, Inflammatory response, Complications, Therapy