Abstract: Objective To investigate the application of warfarin in dealing with portal vein thrombosis （PVT） in patients with liver cirrhosis after splenectomy and devascularization. Methods A retrospective analysis of the clinical data was made in 48 patients with cirrhosis and PVT after plenectomy and devascularization between April 2010 and September 2015 in Beijing You’an Hospital. 25 patients took warfarin for 1 months and 3 patients took warfarin for 6 months after the operation. The changes of PVT after splenectomy and devascularization was compared between the two groups according to the US examination. Results Out of the 48 patients with PVT,the PVT progressed in 20 cases （41.7%）,and 6 cases（26.1%） of them was from patients who took warfarin for 6 months,and 14 （56%） was from patients who took warfarin for one month （P<0.05）;the PVT significantly progressed in 11 cases（22.9%）,including 9 cases（36%） in patients taking warfarin for one month and 2 cases（8.7%） in patients taking warfarin for 6 months（P=0.039）;the incidences of repatency of PVT, rebleeding,liver cancer and death in patients taking warfarin shortly were 0.0%,4.0%,8.0% and 4.0%,no significantly different as compared to 4.3%,4.3%,4.3% and 0.0%（P>0.05） in patients taking warfarin for six months. Conclusion The application of warfarin in dealing with portal vein thrombosis（PVT） in patients with liver cirrhosis after splenectomy and devascularization is safe and effective,which might stop the progress of PVT and decrease the risk of rebleeding.

Key words: Liver cirrhosis, Portal vein thrombosis, Splenectomy, Devascularization, Warfarin, Prophylaxis and treatment