Abstract: Objective To investigate the influencing factors of prognosis in patients with hilar cholangiocarcinoma（HCCA） after surgical treatment. Methods 120 patients with HCCA were recruited in our hospital between January 2010 and January 2014,and 67 patients received surgical resection,including 30 with radical resection and 37 with R1 or R2 palliative resection,and 53 received bile duct drainage. Results The 1-year,2-year and 3-year survival rates in the 120 patients with HCCA were 67.5% （81/120）,45.8% （55/120） and 25%（30/120）,respectively,after treatment,and the 1-year,2-year and 3-year survival rates in patients undergoing radical resection were 93.33%,73.33%,60.00%,and the survival time was（30.26±5.26） months,much higher than 67.57%,48.65%,32.43% or longer than（22.14±4.78） m in patients with palliative resection or 52.83%,28.30%,0.0% and （15.21±3.74） m in patients with bile duct drainage （P<0.05）;Cox multivariate analysis showed that the surgical method [Exp（β）=5.214],resection margin [Exp（β）=2.703],differentiation degree [Exp（β）=4.781],TNM stage [Exp（β）=6.987],lymph node metastasis [Exp（β）=2.751] and portal vein invasion [Exp（β）=3.254] were the independent risk factors for the prognosis of patients with HCCA after treatment（P<0.05）. Conclusion Precise surgery should be given in patients with HCCA with detailed analysis of influencing factors of prognosis, which might be evaluated before any approaches is taken.

Key words: Hilar cholangiocarcinoma, Surgery, Prognosis