Abstract: Objective To investigate the safety and efficacy of laparoscopic radical cholecystectomy (LRC) in treatment of patients with gallbladder cancer. Methods 40 patients with gallbladder cancer were recruited in our hospital between January 2013 and December 2015,and were randomly divided into two groups. 19 received LRC,and 21 received open radical cholecystectomy. All patients were followed-up for two years,and the overall survival was estimated by Kaplan-Meier analysis. Results The operation time,the numbers of lymph nodes cleared and bleeding in the LRC group were（238.4±31.2）min,（7.5±1.2） and（210.5±21.1）ml,while they were [（316.5±11.5）min（P<0.01),（7.8±0.9） and（301.2±22.8）ml（P<0.01),in the open redical cholecystectomy, respectively];the ambulation time,stoping drainage time,eating time,postoperative exhaust time and hospitalization time were（2.1±0.5）d,（3.5±2.1）d,（2.5±0.9）d,（1.1±0.1）d and （5.4±2.1）d,much shorter than in the open redical cholecystectomy [（7.1±1.2）d,（14.5±6.6）d,（3.8±1.8）d,（1.9±0.5）d and （8.2±5.8）d,respectively,P<0.01】;infection and bile leak occurred in one and two patients （15.8 %） in LRC group,much lower than four and five（42.9%,x²=4.286,P=0.038） in the open redical cholecystectomy;the 1 year survival rates in LRC and in open redical cholecystectomy group were 94.7% and 95.2%,and 2 year survival rates were 78.9 % and 71.4 %,respectively in the two groups（x²=0.655,P=0.418）;abdominal lymph node metastasis occurred in two patients in LRC group and in three in patients underwent open redical cholecystectomy. Conclusion LRC is safe and feasible for the treatment of patients with gallbladder cancer, and the efficacy is similar to that,but hospitalization time is shorter than that with open radical cholecystectomy.

Key words: Gallbladder cancer, Laparoscopy, Radical resection, Efficacy