Abstract: Objective To analyze blood glucose and total cholesterol （TC） in the prognosis of patients with liver failure （LF）. Methods A retrospective analysis was performed on 106 LF patients who were admitted to in our hospital. The patients were divided into blood TC≤1.0 mmol/L group（n=8）,1.0 mmol/L<TC≤2.0 mmol/L group（n=49） and TC>2.0 mmol/L group（n=49） according to the TC level at admission. After excluding 10 patients with diabetes,96 patients were divided into normal blood glucose group （n=60）,hyperglycemia group （n=12） and hypoglycemia group（n=24） according to the blood glucose levels at admission. The correlation between blood glucose or TC and survival rate was compared respectively. TC was dynamically monitored in 81 patients with TC>1.0 mmol/L at admission to explore the relationship between the dynamic changes of TC and the prognosis of patients with LF. Results Hepatitis B virus（HBV） infection was the main cause of LF in the 106 patients, accounting for 66.0% and the proportion of chronic liver failure（CLF） accounted for 46.2%;the survival rate in patients with hypoglycemia at admission was 41.7%,significantly lower than that in patients with normal blood glucose （71.7%,P<0.01）;there were significant differences in survival rates between patients with blood TC≤1.0 mmol/L group,1.0 mmol/L<TC≤2.0 mmol/L group and TC>2.0 mmol/L group and the lower the baseline TC levels,the lower the survival rates（12.5% vs. 51.0% vs. 75.5%,respectively,P<0.05 for all）;the survival rate in patients with a declining levels of TC during hospitalization was 28.6%,significantly lower than that in patients with an increasing trend （93.5%,P<0.05）. Conclusion Hypoglycemia and blood TC≤2.0 mmol/L at admission or decreased TC level trend are associated with poor prognosis of patients with LF,especially in patients with blood TC≤1.0 mmol/L at admission.

Key words: Liver failure, Blood glucose, Total cholesterol, Prognosis