Abstract: Objective To validate the prediction of short-term survival by four scoring systems based on models for end-stage liver disease（MELD） in patients with acute-on-chronic hepatitis B-induced liver failure （HBV-ACLF）. Methods 67 patients with HBV-ACLF were enrolled in this study between April 2015 and October 2017. The clinical parameters were collected for calculation of MELD,iMELD,MELD-Na and MESO scores,respectively. The predictive efficacy on forecasting survival of patients with HBV-ACLF by the four scoring systems was analyzed by receiver operating characteristic curve（ROC） supported by MedCalc15.8 software. Results 45（67.2%） out of 67 patients with HBV-ACLF died within 12 weeks;the scores of MELD,iMELD,MELD-Na and MESO models at presentation in survival group were （22.12±3.24）,（41.59±5.30）,（22.55±4.07） and （1.64±0.24）,much lower than 【（30.47±9.01）,（51.88±11.09）,（32.35±11.58） and （2.28±0.70）,respectively,P<0.01】 in the dead group;the area under the ROC curve （AUC） in forecasting the survival of patients with HBV-ACLF by the four models were 0.814,0.802,0.806 and 0.817 respectively,the cut-off-values were 22.70,47.76,22.16 and 1.69,and the Jordan index were 0.5040,0.5535,0.4808 and 0.4818,respectively,suggesting no significant differences between them（P>0.05）. Conclusion The four scoring systems base on MELD have good predictive efficacy on forecasting 12 weeks’ survival in patients with HBV-ACLF,which hints they might be applied in clinical practice.

Key words: Acute-on-chronic liver failure, Hepatitis B, Models for end-stage liver disease, Prognosis