Abstract: Objective To evaluate the diagnosis of intrahepatic peripheral cholangiocarcinoma（IHPCC） by spiral computed tomography（CT） and magnetic resonance imaging（MRI）. Methods A total of 80 patients with IHPCC were included in this study. All patients underwent non-enhanced,enhanced,and delayed scanning of spiral CT and MRI examination,and the diagnostic efficacy were estimated by pathologic examination post-operationally or by fine needle biopsy before operation. Results The lesion size ranged from 1.3 cm×2.0 cm to 7.3 cm×9.0 cm （mean 4.6 cm×6.4 cm）;the tumors localized in left lobe in 58 cases,in right lobe in 22 cases;the tumors presented as mass in 46 cases （57.50%）,infiltrating stenosis in 17 cases （21.25%）,growth chamber in 10 cases （12.50%）,and not clear in 7 cases （8.75%）;Unenhanced CT scan showed low-density lesions in all,and enhanced CT scan showed mild to moderate edge enhancement in 50 cases,mild central strip sheet enhancement in 12 cases,and no enhancement in 18 cases;delayed CT scan showed separation of unevenness or sheet-like enhancement in 47 cases,homogeneous enhancement in 5 cases,and no enhancement in 28 cases;Unenhanced MRI scan showed the lesions more clearly than CT,and delayed enhanced MRI scan showed enhancement in 73 cases;the diagnostic accuracy rate of MRI was 91.3%,no statistically significant difference as compared to 80.0% by CT scan（P>0.05）. Conclusions Delayed enhanced CT and MRI scan may improve the diagnostic accuracy of IHPCC, and we recommend MRI in clinical practice.

Key words: Cholangiocarcinoma, Computed tomography, Magnetic resonance imaging, Diagnosis