间充质干细胞修复肝损伤的机制及膜微粒的生物治疗潜力*

doi:10.3969/j.issn.1672-5069.2015.01.028

Abstract

Abstract: Transplantation of mesenchymal stem cells（MSCs） is an promising way in the treatment of cirrhosis and liver failure. The possible mechanisms of MSCs in repair of liver injury are as follows：differentiation to hepatocyte-like cells,paracrine and immunomodulatory effects,and signal transmission mediated by microvesicles （MVs）. Results from present studies suggest that RNA carried by MVs has emerged as an important mechanism by which the stem cells may repair injured cells and MVs transplantation may become a new choice for improving decompensated liver functions. This review will discuss the possible mechanisms of intrahepatic transplanted MSCs and the potential of MVs in the treatment of liver injuries.

Key words: Liver injury, Mesenchymal stem cells, Microvesicles, Treatment

Ruan Chenglan, Chen Congxin. Application of mesenchymal stem cells and microvesicles in the treatment of patients with liver injuries[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2015, 18(1): 97-100.

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Application of mesenchymal stem cells and microvesicles in the treatment of patients with liver injuries

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