Abstract: Objective To explore the anti-oxidant effects of silymarin on intestinal tissues in rats with non-alcoholic steatohepatitis.Methods Fifty Wistar rats were randomly divided into control，model and silymarin groups.The rats in control group were fed with normal diet.The rats in model group were fed with fat rich diet and saline by gastric lavage Methods to establish the model of NASH.The rats in silymarin group were fed with fat rich diet and silymarin by gastric lavage method.All rats in each group were observed for 12 weeks.Results The serum levels of TC，TG，ALT and AST were higher in model group than those in control group.The serum levels of TC，TG，ALT and AST were lower in silymarin group than those in model group（F=36.626～64.327，P<0.01）; The activitives of SOD were lower in model group than in control group（83.29±10.32 U/mgprot vs.52.34±7.09 U/mgprot）.The activitives of SOD in silymarin group were higher than those in model group; The changes of MDA were on the contrary（0.56±0.07 Nmol/mgprot vs.0.97±0.09 Nmol/mgprot，F=23.488 and 10.609，respectively，P<0.05）;The levels of ET in model group（0.316±0.020EU/ml）were higher than in silymarin grou p（0.279±0.022EU/ml）.Conclusion Silymarin，an anti-oxidant drug，can protect the hepatocytes and the intestines in rats with NASH.

Key words: Non-alcoholic steatohepatitis, Silymarin, Oxidative stress