Abstract: Objective To evaluate the curative effect of plasma exchange in the treatment of severe hepatitis by the model for end-stage liver disease. Method 62 patients with severe hepatitis were treated with plasma exchange. Blood chemical data were collected pre-treatment and post-treatment. All of the patients graded with MELD and the fatality rate were observed three months later. Results The concentration of TBil，TBA，ALT in the sera were much lower than post-treatment（P＜0.05）；After plasma exchange treatment，overall death rate of 62 patients was 56.5%，much less than the prediction of mortality（76.3%，P<0.05），especially in the group of patients with MELD score less than 30. Conclusion As a hepatic support device，plasma exchange is a useful way for therapy of severe hepatitis.

Key words: Severe hepatitis, Plasma exchange, MELD