Abstract: Objective To retrospectively analyze the factors influencing the short-term prognosis of patients with chronic severe hepatitis B（CSH）. Methods Clinical data of 155 patients with CSH were retrospectively analyzed. Results 60（38.7%）survived and 95（61.3%）died in this series；PTA（31.26±6.8%）and globulin（32.28±9.13g/l）in survivals were obviously higher than those in dead（26.11±9.76% and 29.32±7.14g/l，P<0.01，P<0.05）；the TBIL（335.74±123.27μmol/L），WBC（6.5±3.0×109/L）and neutrophil ratio（64.42±14.59%）in survivals were obviously lower than in dead（382.78±141.15μmol/L，8.8±5.4×109/L and 71.63±11.37%，P<0.05，P<0.05，P<0.01）；neutrophil ratio，globulin and PTA were strongly related to patients'prognosis. Conclusion It is important to predict the short-term prognosis of patients with CSH.

Key words: Chronic severe hepatitis B, Prognosis, PTA