Abstract: Objective To study the effects of plasma exchange （PE） combined with plasma perfusion （PP） to treat patients with liver failure. Methods 46 patients with liver failure from June 2012 to July 2015 were selected as observation group,and the patients were treated by using PE combined with PP,and another 46 patients with liver failure from January 2007 to May 2008 were selected as control group,and they were treated by using PE alone. Total serum bilirubin（TBIL）,albumin（ALB）,thrombin original time international normalized ratio （INR）,ammonia （NH3） were detected routinely,and serum C-reactive protein （CRP）,tumor necrosis factor -α（TNF-α）,interleukin-6（IL-6） were detected by ELISA. Results The effective rates and total effective rates （41.3%,93.47%） in the observation group were significantly higher than in control group（21.74%,78.26%,P<0.05）;Serum TBIL,INR,NH₃,CRP,TNF-α and IL-6 levels in the observation group was（308.3±35.3） μmol/L, （1.6±0.2）,（214.3±22.7） μmol/L,（7.4±1.1） mg/L,（1128.3±345.3） ng/L and（115.5±12.0） ng/L,significantly lower than in the control group [（326.1±38.4） μmol/L,（1.9±0.8）,（267.5±26.1） μmol/L,（10.3±1.3） mg/L,（2012.3±318.4） ng/L,（184.3±20.1） ng/L,P<0.05];Serum ALB level in the observation group was （34.3±4.9）g/L,significantly higher than in the control group[（31.4±3.9）g/L,P<0.05];The incidence of complications in the observation group was 19.6%, significantly lower than in the control group（36.1%,P<0.05）. Conclusions Plasma exchange and plasma perfusion are helpful to clear inflammatory cytokines,and improve liver function in patients with liver failure.

Key words: Liver failure, Plasma exchange, Plasma perfusion, Inflammatory cytokines