慢性乙型肝炎患者HBV基因型和亚型分布调查

Abstract

Abstract: Objective To study hepatitis B virus （HBV） genotypes and subtypes distribution in chronic hepatitis B patients. Methods Genotype/subtype-specific primer PCR was used to detect HBV genotypes and subtypes in 660 chronic hepatitis B patients from Beijing（n=474）,Shijiazhuang（n=40）,Changchun（n=55）,Dalian（n=20）,Zhengzhou（n=33）, Xi’an（n=26） and Hefei（n=12）. Results Among 660 patients with chronic hepatitis B （all with serum HBV DNA positive）,the prevalences of genotype B,C,and B/C subtype were 16.67%（110/660）,74.54%（492/660）,and 8.79%（58/660）,respectively;In genotype C-infected patients,6（1.22%） were subtype C1,473（96.14%） were subtype C2,and 13（2.64%） were C1/C2 coinfection;All genotype B were subtype Ba;There was no significant difference of HBeAg positivities or serum HBV DNA levels between subtype B and subtype C infected patients. Conclusion The common HBV genotypes in these seven cities are genotype B and C,and genotype C prevail,while subtypes Ba and C2 are predominant.

Key words: Hepatitis B, Hepatitis B virus, Genotype, Subgenotype

YIN Jiming, JIN Ronghua, YAN Yan, et al.. Prevalence of hepatitis B virus genotypes and subtypes in patients with chronic hepatitis B[J]. JOURNAL OF PRACTICAL HEPATOLOGY, 2010, 13(1): 19-21.

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Prevalence of hepatitis B virus genotypes and subtypes in patients with chronic hepatitis B

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