Abstract: Objective The aim of this study was to summarize clinical feature and prognosis of patients primary biliary cirrhosis (PBC) complicated with esophagogastric variceal bleeding (EVB). Methods A retrospective analysis was conducted on 106 patients with PBC and EVB, including first EVB in 33 cases and re-bleeding in 73 cases, who were admitted to our hospital between April, 2021, and December, 2023. The clinical features, laboratory indicators, complications and prognosis were analyzed. Results The ICU admission rate in the first bleeding group was significantly higher than that in re-bleeding group (12.1% vs. 0.0%, P=0.002), and the incidence of portal vein thrombosis was significantly lower than in re-bleeding group (12.1% vs. 32.9%, P=0.025); no significant differences were observed between the two groups as respect to 6-week mortality (9.1% vs. 8.2%, P =0.881), 6-week re-bleeding rate (12.1% vs. 17.8%, P=0.460), and 1-year mortality (16.2% vs. 17.2%, P=0.897). Conclusion PBC patients with decompensated liver functions might complicate EVB, and re-bleeding is very common, which should be carefully intervened with hemostasis, and even endoscopic therapy.

Key words: Primary biliary cirrhosis, Esophagogastric variceal bleeding, Re-bleeding, Portal vein thrombosis, Prognosis