Abstract: Objective The aim of this study was to investigate risk factors of acute liver injury (ALI) in patients with sepsis. Methods 207 patients with sepsis were encountered in our hospital between August 2021 and August 2024, and out of them, ALI was found in 107 cases according to diagnostic criteria. All patients received antibiotics and life-supporting therapy, and those with ALI were carefully dealt with liver-supporting approaches. Serum C-reaction protein (CRP), procalcitonin (PCT) and D-dimer (D-D) levels were determined by fluorescent immunochromatography. Multivariate Logistics regression analysis was applied to analyze the risk factors for ALI occurrence. Results Platelet count and serum albumin level in patients with ALI were (123.6±26.0)×10⁹/L and (29.9±5.4)g/L, both significantly lower than [(170.4±30.3)×10⁹/L and (32.9±6.0)g/L, respectively, P＜0.05], while serum CRP, D-D, APACHE Ⅱ score, ICU stay, mechanical ventilation and intravenous administration of antibiotics were (90.9±18.7)mg/L, (4.1±0.8)μg/ml, (21.5±3.5)points, (11.3±1.5)d, (130.5±13.1)h and (14.4±2.8)d, all significantly higher or longer than [(46.9±8.3)mg/L, (2.3±0.5)μg/ml, (16.7±3.4), (4.8±1.0)d, (45.4±4.8)h and (7.3±1.2)d, respectively, P＜0.05] in patients with sepsis without ALI; multivariate Logistic regression analysis showed that ICU stay, mechanical ventilation, intravenous administration of antibiotics and APACHE Ⅱ score were all the independent risk factors for occurrence of ALI in patients with sepsis(P<0.05). Conclusion The patients with sepsis could be complicated with ALI, and acknowledge of them and giving an early prevention and treatment might improve prognosis of them.

Key words: Acute liver injury, Sepsis, Risk factors, Prognosis