Abstract: Objective The purpose of this study was to summarize the clinical feature of patients with acute portal vein thrombosis (PVT). Methods 15 patients with acute PVT were admitted to The First Affiliated Hospital, Soochow University between January 2020 and April 2022, the etiology, clinical feature, treatments strategy and outcomes were summarized. Results Of the 15 patients with acute PVT, there were 13 males and 2 females, with an average age of (52.5±15.6) years; the etiology included hepatitis B-induced liver cirrhosis (LC) in 5 cases, alcoholic LC in 1 case, primary biliary cholangitis in 1 case, schistosomiasis-induced cirrhosis in 1 case and cryptogenic Cirrhosis in 2 cases, and non-cirrhotics, including non-cirrhotic portal hypertension in 1 case, hereditary protein C deficiency in 1 case and cryptogenic diseases in 3 cases; anticoagulation treatment was initiated in 14 cases, of which 2 patients received interventional thrombolysis and 1 patient received anticoagulation medicine treatment; 2 patients died of septic shock derived from intestinal ischemic necrosis, 1 patient died of hemorrhagic shock derived from esophageal variceal bleeding, PVT didn’t change in 1 case, thrombolysis and vascular recanalization occurred in 2 cases, and thrombosis shrunk in the remaining patients. Conclusion The etiology vary in patients with acute PVT, without specific clinical manifestations, and early diagnosis and intervention might improve the outcomes.

Key words: Acute portal vein thrombosis, Etiology, Clinical feature, Anticoagulation therapy