Abstract: Objective The aim of this study was to investigate the risk factors influencing portal vein thrombosis (PVT) after splenectomy and portoazygous devascularization in patients with hepatitis B-induced liver cirrhosis (LC). Methods A total of 96 patients with hepatitis B-induced LC were encountered in our hospital between January 2022 and December 2024, and all underwent splenectomy and portoazygous devascularization. General clinical materials were obtained routinely, and multivariate Logistic regression analysis was performed to identify risk factors influencing PVT formation. Results Of 96 patients with LC, ultrasonography found PVT in 34 cases (35.4%) three weeks after surgery; Child-Pugh score at baseline in patients with PVT was (10.0±1.4), significantly higher than [(6.9±1.2) in those without (P<0.05), and percentages of prophylactic intravenous administration of low molecular dextran or low molecular heparin for anticoagulant interventions after operation were 8.8% and 14.7%, both much lower than 27.4% and 33.9% (P<0.05) in those without; pre-operational platelet (PLT) count was (64.2±16.9)×10⁹/L, much lower than [(88.0±14.8)×10⁹/L, P<0.05], while it peaked to (180.5±24.1)×10⁹/L post-operationally, much higher than [(126.8±15.0)×10⁹/L, P<0.05] in those without; portal vein diameter, spleen length and spleen thickness at admission were much greater than, while portal blood flow velocity was much slower than in those without (P<0.05); multivariate Logistic regression analysis demonstrated that pre-operational Child-Pugh score and post-operational PLT counts were the independent risk factors for PVT formation after surgery (P<0.05), while post-operational anticoagulant measures exhibited protective roles(P<0.05). Conclusion The risk factors promoting PVT formation after splenectomy and portoazygos devascularization in patients with LC should be taken into consideration, as appropriate prophylactic interventions might prevent it occurrence and promote prognosis.

Key words: Liver cirrhosis, Splenectomy, Portoazygous devascularization, Portal vein thrombosis, Risk factors