Abstract: Objective The purpose of this study was to investigate Doppler tissue imaging (DTI) and echocardiography (ECG) index in diagnosing cirrhotic cardiomyopathy (CCM) in patients with hepatitis B-induced liver cirrhosis (LC). Methods 120 patients with hepatitis B-induced LC were encountered in Second Affiliated Hospital, Xi 'an Medical University between February 2019 and February 2024, all patients underwent DTI and ECG for left atrial diameter (LAD)and ratio of peak velocity of left ventricular diastolic blood flow in early and late stages (E/A ratio), etc., and transferred to TDI model for detection and calculation of Tei index. Univariate and multivariate Logistic regression analysis was used to reveal influencing factors of occurrence of CCM, and the area under the receiver-operating characteristic (ROC) curve (AUC) was applied to assess diagnostic performance. Results Of 120 patients with LC, CCM was found in 37 cases(30.8%)base on QT-c interval＞440ms; ages, percentages of smoking, alcohol hobby, Child-Pugh class C, total serum bilirubin and creatine kinase isoenzyme (CKMB) levels in patients with CCM were (62.6±5.9)yr, 43.2%, 62.2%, 35.1%, (47.3±9.4)μmol/l and (28.4±6.3)U/l, all significantly higher or greater than [(58.2±5.4)yr, 8.4%, 4.8%, 4.8%, (14.8±7.4)μmol/l and (20.9±4.8)U/l, respectively, P＜0.05] in cirrhotics without CCM; portal vain diameter, LAD and Tei index in patients with CCM were (16.2±2.1)mm, (39.6±4.4)mm and (0.6±0.2), all significantly greater than [(13.2±1.2)mm, (34.2±3.6)mm and (0.4±0.1), respectively, P＜0.05], while E/A ratio was (0.8±0.1), much less than [(1.0±0.2), P＜0.05] in patients with LC; multivariate Logistic regression analysis showed that ages, Child-Pugh class, LAD and Tei index were all the independent risk factors for occurrence of CCM in patients with LC (P＜0.05);ROC analysis demonstrated that the AUCwas 0.901(95%CI:0.836-0.967), with sensitivity of 86.5% and specificity of 84.3%, when LAD and Tei index combination was applied to predict CCM in patients with LC, much superior to any one parameter did (P＜0.05). Conclusion Combination of LAD and Tei index could help clinicians find secondary CCM in patients with LC early, which might guide them to take appropriate measures.

Key words: Liver cirrhosis, Cirrhotic cardiomyopathy, Doppler tissue imaging, Echocardiography, Tei index, Diagnosis