Abstract: Objective The aim of this study was to observe the short-term efficacy of regular hepatic lobectomy in patients with complicated hepatolithiasis. Methods 298 patients with complicated hepatolithiasis were admitted to our hospital between January 2019 and June 2020, and 139 patients underwent regular (observation) and another 159 patients underwent irregular (control) hepatic lobectomy. All patients were followed up for 6 months after surgery. Serum interleukin-6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP)] levels were detected by enzyme-linked immunosorbent assay or double antibody sandwich immunoluminescence. Results The operation time in observation group was significantly longer than that in control group [(121.3±25.2) min vs. (116.7±22.8) min, P<0.05], while intraoperative blood loss, anal exhaust time and hospital stay were significantly less or shorter than those in the control group [(252.3±60.0) mL, (18.9±3.2) h and (11.2±2.3) d vs. (301.7±70.2) mL, (20.1±4.1) h and (14.5±3.5) d, respectively, P<0.05]; at the end of seven days after surgery, serum CRP, IL-6 and PCT levels in the observation group were (23.8±6.0) mg/L, (80.8±10.1) μg/L and (1.4±0.5) ng/mL, all significantly lower than those in the control group [(27.9±6.8) mg/L, (96.7±11.3) μg/L and (1.8±0.4) ng/mL, respectively, P<0.05]; serum albumin level was significantly higher than that in the control group [(34.1±2.9) g/L vs. (32.5±2.7) g/L, P<0.05]; at the end of six month follow-up, the incidence rate of complications, such as incision infection, bile leakage, biliary hemorrhage and pleural effusion in observation group was 7.9%, significantly lower than 15.7% in the control group (P＜0.05), and the recurrence rate of intrahepatic stone was 11.5%, significantly lower than 23.9%(P＜0.05) in the control. Conclusion The application of regular hepatic lobectomy isefficacious in treating patients with complicated hepatolithiasis, which might lead to less inflammatory reactions, and needs further and long-term observation.

Key words: Hepatolithiasis, Complicated hepatolithiasis, Regular hepatic hepatectomy, Complication, Treatment