Abstract: Objective The purpose of this study was to investigate the application of segmental hepatectomy for the treatment of patients with hepatolithiasis and effect on serum leukotriene (LTB4) and hepatic carbon monoxide (CO) levels. Methods 60 patients with hepatolithiasis were admitted to our hospital between June 2015 and December 2019, and were randomly divided into observation (n=30) and control group (n=30). The patients in the observation group were treated with segmental hepatectomy, and those in the control group were treated with B-ultrasound-guided hepatectomy. Serum LTB4 and liver tissue CO were detected and compared in the two groups. Results The bleeding volume in the observation group was (351.7±104.2) mL, significantly lower than [(492.6±153.8)mL, P<0.05], and the drainage volume was (279.8±79.2) mL, much lower than [(361.7±113.7)mL, P<0.05] in the control; serum LTB4 level was (22.6±11.7) ng/L/l, significantly lower than t [(43.5±12.2) ng/L/l, P<0.05], and hepatic CO concentration was (41.3±5.8) ppm, much lower than [(65.5±4.3) ppm, P<0.05] in the control; the incidence of complications in the observation group was 23.3%, significantly lower than 50.0% in the control group (P<0.05). Conclusion The application of segmental hepatectomy could effectively reduce intraoperative blood loss, post-operational drainage, serum LTB4 level and hepatic CO concentration in patients with hepatolithiasis, which might be related to the inhibition of inflammatory reactions.

Key words: Hepatolithiasis, Segmental hepatectomy, Leukotriene B4, Carbon monoxide, Complications